nlmixr2auto is a fully automated population pharmacokinetic (PopPK) modeling tool that enables end to end model development within the nlmixr2 ecosystem with minimal user intervention. Users only need to provide a dataset and the framework can generate data driven initialization, perform model evaluation, and apply metaheuristic optimization to support automated model selection and parameter estimation. It supports multiple search and optimization strategies including genetic algorithms, ant colony optimization, tabu search, and stepwise procedures to explore candidate structural, variability, and residual error models and refine parameter estimates. Nlmixr2auto streamlines PopPK workflow execution by promoting automated model building and enabling algorithm driven exploration of model space within nlmixr2.
Installation
You can install nlmixr2auto either from CRAN or from the development version on GitHub:
From CRAN (stable release)
install.packages("nlmixr2auto",dependencies = TRUE)From GitHub (development version)
For additional information on installing the broader nlmixr2 ecosystem,such as compiler configuration, system requirements, and platform-specific setup—please see the installation instructions in the main nlmixr2 repository(https://github.com/nlmixr2/nlmixr2). A nlmixr2autoinit tutorial is available at https://nlmixr2auto.org/.
Examples
Stepwise model building algorithm
This basic example demonstrates how the stepwise model building algorithm implemented in this package can be used to automate model development and optimization of pheno_sd (nlmixr2data::pheno_sd) for the intravenous case.
library(nlmixr2)
library(nlmixr2autoinit)
library(nlmixr2auto)
outs <- sf.operator(
dat = pheno_sd, # Dataset used for model fitting
search.space = "ivbase", # Structural search space for IV PK models
filename = "pheno_sd", # Prefix for output files
foldername = "pheno_sd", # Folder where results will be stored
saem.control = saemControl( # SAEM estimation control settings
nBurn = 200, # SAEM burn-in iterations
nEm = 300, # SAEM EM-phase iterations
rxControl = rxControl(cores = 4),# CPU cores for ODE solving
logLik = TRUE # Compute log-likelihood
),
table.control = tableControl(
cwres = TRUE # Compute conditional weighted residuals (CWRES)
),
max_wall_time = 2 * 60 * 60 # Maximum allowed wall-clock time (seconds) per model; here: 2 hours
)
print(outs)Click to view Stepwise output
# Infometrics Value
# ---------------------------------------- ---------------
# Dose Route bolus
# Dose Type combined_doses
# Number of Subjects 59
# Number of Observations 155
# Subjects with First-Dose Interval Data 35
# Observations in the First-Dose Interval 35
# Subjects with Multiple-Dose Data 56
# Observations after Multiple Doses 120
# ---------------------------------------- ------
# Estimating half-life....................
# Half-life estimation complete: Estimated t1/2 = 16.44 h
# Evaluating the predictive performance of calculated one-compartment model parameters....................
# Base PK parameter analysis finished. Estimated ka: NA, estimated CL: 0.0087, estimated Vd: 1.25
# Run parameter sweeping on nonlinear elimination kinetics PK parameters....................
# Run parameter sweeping on multi-compartmental PK parameters....................
# Running Step 1: Number of compartments ----------------------------------------------------
# Loaded cached model results from 'pheno_sd_sf/pheno_sd_sf.csv'.
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_sf/mod1.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_sf/mod2.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_sf/mod3.txt
# Running Step 2: Elimination type ----------------------------------------------------
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_sf/mod4.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_sf/mod5.txt
# Running Step 3: IIV on Km ----------------------------------------------------
# Step 3: IIV on Km skipped.
# Running Step 5: IIV (forward selection) ----------------------------------------------------
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_sf/mod6.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_sf/mod7.txt
# Running Step 6: ETA correlation ----------------------------------------------------
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_sf/mod8.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_sf/mod9.txt
# Running Step 7: Residual error model ----------------------------------------------------
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_sf/mod10.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_sf/mod11.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_sf/mod12.txt
# > print(pheno_sd_sf)
#
# === Best Model Code ===
# no.cmpt eta.vmax eta.km eta.cl eta.vc eta.vp eta.vp2 eta.q eta.q2 mm mcorr rv
# 1 1 0 0 1 1 0 0 0 0 0 1 1
#
# === Best Model Name ===
# bolus_1cmpt_etaCLVC_FOelim_correlated_add
#
# === Stepwise Selection History ===
# Step Penalty.terms Model.name Model.code Fitness AIC BIC OFV
# 1 No. of compartments rse, theta, covariance bolus_1cmpt_etaCL_FOelim_uncorrelated_combined 1,0,0,0,0,0,0,0,0,3 21185.358 1170.1409 1185.358 875.2699
# 2 Elimination type rse, theta, covariance bolus_1cmpt_etaCL_FOelim_uncorrelated_combined 1,0,0,0,0,0,0,0,0,3 21185.358 1170.1409 1185.358 875.2699
# 5 IIV (forward) rse, theta, covariance, shrinkage, omega bolus_1cmpt_etaCLVC_FOelim_uncorrelated_combined 1,0,1,0,0,0,0,0,0,3 11104.215 1085.9549 1104.215 789.0840
# 6 Eta correlation rse, theta, covariance, shrinkage, omega, correlation bolus_1cmpt_etaCLVC_FOelim_correlated_combined 1,0,1,0,0,0,0,0,1,3 1097.977 1066.6730 1087.977 767.8021
# 7 Residual error types rse, theta, covariance, shrinkage, omega, correlation, sigma bolus_1cmpt_etaCLVC_FOelim_correlated_add 1,0,1,0,0,0,0,0,1,1 1014.616 986.3554 1004.616 689.4845Genetic algorithms
This basic example demonstrates how the genetic algorithm implemented in this package can be used to automate model development and optimization of pheno_sd (nlmixr2data::pheno_sd) for the intravenous case.
pheno_sd_ga <- ga.operator(
seed = 20,
dat = pheno_sd, # Dataset used for model fitting
search.space = "ivbase", # Structural search space for IV PK models
filename = "pheno_sd_ga", # Prefix for output files
foldername = "pheno_sd_ga", # Folder where results will be stored
saem.control = saemControl( # SAEM estimation control settings
nBurn = 200, # SAEM burn-in iterations
nEm = 300, # SAEM EM-phase iterations
rxControl = rxControl(cores = 4),# CPU cores for ODE solving
logLik = TRUE # Compute log-likelihood
),
table.control = tableControl(
cwres = TRUE # Compute conditional weighted residuals (CWRES)
),
max_wall_time = 2 * 60 * 60 # Maximum allowed wall-clock time (seconds) per model; here: 2 hours
)
print(pheno_sd_ga)Click to view GA output
# Infometrics Value
# ---------------------------------------- ---------------
# Dose Route bolus
# Dose Type combined_doses
# Number of Subjects 59
# Number of Observations 155
# Subjects with First-Dose Interval Data 35
# Observations in the First-Dose Interval 35
# Subjects with Multiple-Dose Data 56
# Observations after Multiple Doses 120
# ---------------------------------------- ------
# Estimating half-life....................
# Half-life estimation complete: Estimated t1/2 = 16.44 h
# Evaluating the predictive performance of calculated one-compartment model parameters....................
# Base PK parameter analysis finished. Estimated ka: NA, estimated CL: 0.0087, estimated Vd: 1.25
# Run parameter sweeping on nonlinear elimination kinetics PK parameters....................
# Run parameter sweeping on multi-compartmental PK parameters....................
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod1.txt
# SAEM control (core) = niter=200|300; nBurn=200; nEm=300; seed=99; print=1
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod2.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod3.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod4.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod5.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod6.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod7.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod8.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod9.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod10.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod11.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod12.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod13.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod14.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod15.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod16.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod17.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod18.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod19.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod20.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod21.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod22.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod23.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod24.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod25.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod26.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod27.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod28.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod29.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod30.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod31.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod32.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod33.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod34.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod35.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod36.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod37.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod38.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod39.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod40.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod41.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod42.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod43.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod44.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod45.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod46.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod47.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod48.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod49.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod50.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod51.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod52.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod53.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod54.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod55.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod56.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod57.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod58.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod59.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod60.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod61.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod62.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod63.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod64.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod65.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod66.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod67.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod68.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod69.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod70.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod71.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod72.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod73.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod74.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod75.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod76.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod77.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod78.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod79.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod81.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod82.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod83.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod84.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod85.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod86.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod87.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod88.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod89.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod90.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod91.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod92.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod93.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod94.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod96.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod97.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod98.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod101.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod102.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod104.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod105.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod106.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod108.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod109.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod110.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod113.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod114.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod115.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod116.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod117.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod118.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod119.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod120.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod121.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod122.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod123.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod124.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod125.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod126.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod127.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod128.txt
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# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod129.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod130.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod131.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod132.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod133.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod134.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod135.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod136.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod137.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod138.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod139.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod140.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod141.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod142.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod143.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod144.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod145.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod146.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod147.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod148.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod149.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod150.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod151.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod152.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod153.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod154.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod155.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod156.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod157.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod158.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod159.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod160.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod161.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod162.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod163.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod164.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod165.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod166.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod167.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod168.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod169.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod170.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod171.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod172.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod173.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod174.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod175.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod176.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod177.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod178.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod179.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod180.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod181.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod182.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod183.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod184.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod185.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod186.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod187.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod188.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod189.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod190.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod191.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod192.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod193.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod194.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod195.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod196.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod197.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod198.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod199.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod200.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod201.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod202.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod203.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod204.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod205.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod206.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod207.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod208.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod209.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod210.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod211.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod212.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod213.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod214.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod215.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod216.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod217.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod218.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod219.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod220.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod221.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod222.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod223.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod224.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod225.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod226.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod227.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod228.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod229.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod230.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod231.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod232.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod233.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod234.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod235.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod236.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod237.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod238.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod239.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod240.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod241.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod242.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod243.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod244.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod245.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod246.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod247.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod248.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod249.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod250.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod251.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod252.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod253.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod254.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod255.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod256.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod257.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod258.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod259.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod260.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod261.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod262.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod263.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod264.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod265.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod266.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod267.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod268.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod269.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod270.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod271.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod272.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod273.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod274.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod275.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod276.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod277.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod278.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod279.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod280.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod281.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod282.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod283.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod284.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod285.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod286.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod287.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod288.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod289.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod290.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod291.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod292.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod293.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod294.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod295.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod296.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod297.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod298.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod299.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod300.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod301.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod302.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod303.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod304.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod305.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod306.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod307.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod308.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod309.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod310.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod311.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod312.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod313.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod314.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod315.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod316.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod317.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod318.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod319.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod320.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod321.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod322.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod323.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod324.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod325.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod326.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod327.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod328.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod329.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod330.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod331.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod332.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod333.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod334.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod335.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod336.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod337.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod338.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod339.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod340.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod341.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod342.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod343.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod344.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod345.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod346.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod347.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod348.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod349.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod350.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod351.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod352.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod353.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod354.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod355.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod356.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod357.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod358.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod359.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod360.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod361.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod362.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod363.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod364.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod365.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod366.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod367.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod368.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod369.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod370.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod371.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod372.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod373.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod374.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod375.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod376.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod377.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod378.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod379.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod380.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod381.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod382.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod383.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod384.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod385.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod386.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod387.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod388.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod389.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod390.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod391.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod392.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod393.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod394.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod395.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod396.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod397.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod398.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod399.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod400.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod401.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod402.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod403.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod404.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod405.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod406.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod407.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod408.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod409.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod410.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod411.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod412.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod413.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod414.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod415.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod416.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod417.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod418.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod419.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod420.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod421.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod422.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod423.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod424.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod425.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod426.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod427.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod428.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod429.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod430.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod431.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod432.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod433.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod434.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod435.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod436.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod437.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod438.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod439.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod440.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod441.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod442.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod443.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod444.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod445.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod446.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod447.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_ga/mod448.txt
# >
# > print(pheno_sd_ga)
#
# === Final Selected Model Code ===
# no.cmpt1 no.cmpt2 eta.km eta.vc eta.vp eta.vp2 eta.q eta.q2 mm mcorr rv1 rv2
# 1 0 1 0 1 0 0 0 0 0 1 0 1
#
# === Final Selected Model Name ===
# bolus_1cmpt_etaCLVC_FOelim_correlated_add Ant colony optimization algorithms
This basic example demonstrates how the ant colony optimization algorithm implemented in this package can be used to automate model development and optimization of pheno_sd (nlmixr2data::pheno_sd) for the intravenous case.
pheno_sd_aco <- aco.operator(
seed = 20, # Random seed for aco
dat = pheno_sd, # Dataset used for model fitting
search.space = "ivbase", # Structural search space for IV PK models
filename = "pheno_sd_aco", # Prefix for output files
foldername = "pheno_sd_aco", # Folder where results will be stored
saem.control = saemControl( # SAEM estimation control settings
nBurn = 200, # SAEM burn-in iterations
nEm = 300, # SAEM EM-phase iterations
rxControl = rxControl(cores = 4),# Number of cores for ODE solving.
logLik = TRUE # Compute log-likelihood
),
table.control = tableControl(
cwres = TRUE # Compute conditional weighted residuals (CWRES)
),
max_wall_time = 2 * 60 * 60 # Maximum allowed wall-clock time (seconds) per model; here: 2 hours
)
print(pheno_sd_aco) Click to view ACO output
# Infometrics Value
# ---------------------------------------- ---------------
# Dose Route bolus
# Dose Type combined_doses
# Number of Subjects 59
# Number of Observations 155
# Subjects with First-Dose Interval Data 35
# Observations in the First-Dose Interval 35
# Subjects with Multiple-Dose Data 56
# Observations after Multiple Doses 120
# ---------------------------------------- ------
# Estimating half-life....................
# Half-life estimation complete: Estimated t1/2 = 16.44 h
# Evaluating the predictive performance of calculated one-compartment model parameters....................
# Base PK parameter analysis finished. Estimated ka: NA, estimated CL: 0.0087, estimated Vd: 1.25
# Run parameter sweeping on nonlinear elimination kinetics PK parameters....................
# Run parameter sweeping on multi-compartmental PK parameters....................
# Loaded cached model results from 'pheno_sd_aco/pheno_sd_aco.csv'.
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod1.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod2.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod3.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod4.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod5.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod6.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod7.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod8.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod9.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod10.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod11.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod12.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod13.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod14.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod15.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod16.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod17.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod18.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod19.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod20.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod21.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod22.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod23.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod24.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod25.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod26.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod27.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod28.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod29.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod30.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod31.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod32.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod33.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod34.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod35.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod36.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod37.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod38.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod39.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod40.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod41.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod42.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod43.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod44.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod45.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod46.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod47.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod48.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod49.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod50.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod51.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod52.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod53.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod54.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod55.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod56.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod57.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod58.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod59.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod60.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod61.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod62.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod63.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod64.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod65.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod66.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod67.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod68.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod69.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod70.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod71.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod72.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod73.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod74.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod75.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod76.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod77.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod78.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod79.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod80.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod81.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod82.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod83.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod84.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod85.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod86.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod87.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod88.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod89.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod90.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod91.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod92.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod93.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod94.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod95.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod96.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod97.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod98.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod99.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod100.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod101.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod102.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod103.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod104.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod105.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod106.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod107.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod108.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod109.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod110.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod111.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod112.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod113.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod114.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod115.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod116.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod117.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod118.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod119.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod120.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod121.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod122.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod123.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod124.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod125.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod126.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod127.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod128.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod129.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod130.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod131.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod132.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod133.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod134.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod135.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod136.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod137.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod138.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod139.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod140.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod141.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod142.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod143.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod144.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod145.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod146.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod147.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod148.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod149.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod150.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod151.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod152.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod153.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod154.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod155.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod156.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod157.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod158.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod159.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod160.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod161.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod162.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod163.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod164.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod165.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod166.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod167.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod168.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod169.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod170.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod171.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod172.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod173.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod174.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod175.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod176.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod177.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod178.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod179.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod180.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod181.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod182.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod183.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod184.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod185.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod186.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod187.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod188.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod189.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod190.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod191.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod192.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod193.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod194.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod195.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod196.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod197.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod198.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod199.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod200.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod201.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod202.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod203.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod204.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod205.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod206.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod207.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod208.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod209.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod210.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod211.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod212.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod213.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod214.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod215.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod216.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod217.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod218.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod219.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod220.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod221.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod222.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod223.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod224.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod225.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod226.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod227.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod228.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod229.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod230.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod231.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod232.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod233.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod234.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod235.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod236.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod237.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod238.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod239.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod240.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod241.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod242.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod243.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod244.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod245.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod246.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod247.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod248.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod249.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod250.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod251.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod252.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod253.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod254.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod255.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod256.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod257.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod258.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod259.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod260.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod261.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod262.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod263.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod264.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod265.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod266.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod267.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod268.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod269.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod270.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod271.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod272.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod273.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod274.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod275.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod276.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod277.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod278.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod279.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod280.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod281.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod282.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod283.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod284.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod285.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod286.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod287.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod288.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod289.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod290.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod291.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod292.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod293.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod294.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod295.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod296.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod297.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod298.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod299.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_aco/mod300.txt
# > print(pheno_sd_aco)
#
# === Final Selected Model Code (ACO) ===
# no.cmpt eta.km eta.vc eta.vp eta.vp2 eta.q eta.q2 mm mcorr rv
# 67 1 0 1 0 0 0 0 0 1 1
#
# === Final Selected Model Name (ACO) ===
# bolus_1cmpt_etaCLVC_FOelim_correlated_add Tabu search algorithm
This basic example demonstrates how the tabu search algorithm implemented in this package can be used to automate model development and optimization of pheno_sd (nlmixr2data::pheno_sd) for the intravenous case.
pheno_sd_tabu <- tabu.operator(
dat = pheno_sd, # Dataset used for model fitting
search.space = "ivbase", # Structural search space for IV PK models
filename = "pheno_sd_tabu", # Prefix for output files
foldername = "pheno_sd_tabu", # Folder where results will be stored
saem.control = saemControl( # SAEM estimation control settings
nBurn = 200, # SAEM burn-in iterations
nEm = 300, # SAEM EM-phase iterations
rxControl = rxControl(cores = 4),# CPU cores for ODE solving
logLik = TRUE # Compute log-likelihood
),
table.control = tableControl(
cwres = TRUE # Compute conditional weighted residuals (CWRES)
),
max_wall_time = 2 * 60 * 60 # Maximum allowed wall-clock time (seconds) per model; here: 2 hours
)
print(pheno_sd_tabu)Click to view tabu output
# Infometrics Value
# ---------------------------------------- ---------------
# Dose Route bolus
# Dose Type combined_doses
# Number of Subjects 59
# Number of Observations 155
# Subjects with First-Dose Interval Data 35
# Observations in the First-Dose Interval 35
# Subjects with Multiple-Dose Data 56
# Observations after Multiple Doses 120
# ---------------------------------------- ------
# Estimating half-life....................
# Half-life estimation complete: Estimated t1/2 = 16.44 h
# Evaluating the predictive performance of calculated one-compartment model parameters....................
# Base PK parameter analysis finished. Estimated ka: NA, estimated CL: 0.0087, estimated Vd: 1.25
# Run parameter sweeping on nonlinear elimination kinetics PK parameters....................
# Run parameter sweeping on multi-compartmental PK parameters....................
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod1.txt
# SAEM control (core) = niter=200|300; nBurn=200; nEm=300; seed=99; print=1
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod2.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod3.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod4.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod5.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod6.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod7.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod8.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod9.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod10.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod11.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod12.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod13.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod14.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod15.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod16.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod17.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod18.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod19.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod20.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod21.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod22.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod23.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod24.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod25.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod26.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod27.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod28.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod29.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod30.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod31.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod32.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod33.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod34.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod35.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod36.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod37.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod38.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod39.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod40.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod41.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod42.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod43.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod44.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod45.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod46.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod47.txt
# Iteration 6: candidate already used as a starting point. Applying 2-bit perturbation to avoid cycling.
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod48.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod49.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod50.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod51.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod52.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod53.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod54.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod55.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod56.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod57.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod58.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod59.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod60.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod61.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod62.txt
# Iteration 8: candidate already used as a starting point. Applying 2-bit perturbation to avoid cycling.
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod63.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod64.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod65.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod66.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod67.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod68.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod69.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod70.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod71.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod72.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod73.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod74.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod75.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod76.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod77.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod78.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod79.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod80.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod81.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod82.txt
# Iteration 10: candidate already used as a starting point. Applying 2-bit perturbation to avoid cycling.
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod83.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod84.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod85.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod86.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod87.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod88.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod89.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod90.txt
# Iteration 11: candidate already used as a starting point. Applying 2-bit perturbation to avoid cycling.
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod91.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod92.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod93.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod94.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod95.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod96.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod97.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod98.txt
# Iteration 12: candidate already used as a starting point. Applying 2-bit perturbation to avoid cycling.
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod99.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod100.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod101.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod102.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod103.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod104.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod105.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod106.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod107.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod108.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod109.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod110.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod111.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod112.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod113.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod114.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod115.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod116.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod117.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod118.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod119.txt
# Iteration 14: candidate already used as a starting point. Applying 2-bit perturbation to avoid cycling.
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod120.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod121.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod122.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod123.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod124.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod125.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod126.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod127.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod128.txt
# Iteration 15: candidate already used as a starting point. Applying 2-bit perturbation to avoid cycling.
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod129.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod130.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod131.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod132.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod133.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod134.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod135.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod136.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod137.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod138.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod139.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod140.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod141.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod142.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod143.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod144.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod145.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod146.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod147.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod148.txt
# Iteration 17: candidate already used as a starting point. Applying 2-bit perturbation to avoid cycling.
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod149.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod150.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod151.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod152.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod153.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod154.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod155.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod156.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod157.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod158.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod159.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod160.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod161.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod162.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod163.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod164.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod165.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod166.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod167.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod168.txt
# Iteration 19: candidate already used as a starting point. Applying 2-bit perturbation to avoid cycling.
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod169.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod170.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod171.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod172.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod173.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod174.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod175.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod176.txt
# [Success] Model file created:
# /home/zhonghuihuang/Desktop/nlmixr2autotest/pheno_sd_tabu/mod177.txt
# Iteration 20: candidate already used as a starting point. Applying 2-bit perturbation to avoid cycling.
# >
# > print(pheno_sd_tabu)
#
# === Final Selected Model Code (Tabu Search) ===
# no.cmpt eta.km eta.vc eta.vp eta.vp2 eta.q eta.q2 mm mcorr rv
# 1 0 1 0 0 0 0 0 1 1
#
# === Final Selected Model Name (Tabu Search) ===
# bolus_1cmpt_etaCLVC_FOelim_correlated_add